Hydrazinecarbothioamides and 1,3,4-Thia/Oxadiazoles Derivatives with Potential Biological Activity Synthesis and Spectral Characterization
نویسندگان
چکیده
STEFANIA-FELICIA BARBUCEANU1, CONSTANTIN DRAGHICI2, LAURA-ILEANA SOCEA1*, CRISTIAN ENACHE3, CRISTINA ANDREESCU4, GABRIEL SARAMET5 1 University of Medicine and Pharmacy “Carol Davilaî, Faculty of Pharmacy, Organic Chemistry Department, 6 Traian Vuia Str., 020956, Bucharest, Romania 2 Organic Chemistry Center “Costin D. Nenitescu”, 202B Splaiul Independentei, 060023, Bucharest, Romania 3 Central Laboratory for Fito-Sanitary Quarantine, 11 Soseaua Afumati, 077190, Bucharest, Romania 4 University of Medicine and Pharmacy “Carol Davila”, Faculty of Medicine, Foreign Languages Department, 8 Eroilor Sanitari Blvd., 050474, Bucharest, Romania 5 University of Medicine and Pharmacy “Carol Davilaî, Faculty of Pharmacy, Pharmaceutical Technology Department, 6 Traian Vuia Str., 020956, Bucharest, Romania
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Synthesis, Characterization and Anti-Inflammatory Activity of Some 1, 3,4 -Oxadiazole Derivatives
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A series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (C1-C7) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. All the synthesis compounds have been characterized by 1HNMR, IR and Mass spectral data. The compounds were purified...
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